![]() Results: RV, ORV and ARV inhibit bladder cancer cells growth in a dose- and time-dependent manner, and exert the anti-tumor potency to T24 cells in order of ORV>ARV>RV>PD. ![]() Then the drug metabolites, in alive and dead T24 cells, also in T24 cell supernatant and lysates, are qualitatively and quantitatively analyzed by high-performance liquid chromatography, liquid chromatography coupled with tandem mass spectrum and high-resolution mass spectrometry technologies, respectively. Methods: Drug sensitivity is evaluated by MTT assay, HE staining and flow cytometry analysis after T24 cells treated with RV, PD, ORV and ARV, respectively. So in this paper, we explore the structure–activity relationship and the metabolic profiles of RV and its analogs (polydatin, oxyresveratrol, acetylresveratrol ) in human bladder cancer T24 cells, and then evaluate their active forms and key chemical functional groups which may determine the fate of tumor cells. ![]() However, the better bioavailability has been found in some RV derivatives. Purpose: Resveratrol (RV), a promising anti-cancer candidate, is limited in application for its poor bioavailability.
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